Title:
認知症の統合失調症の治療のためのｍＧｌｕ５受容体活性のアロステリックモジュレーターとしての１，２，４−トリアゾール
Document Type and Number:
Japanese Patent JP5820538
Kind Code:
B2
Abstract:
This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.
Inventors:
Grauert Matthias
Bischoff Daniel
Derman Georg
Curzer Raimund
Rudolph Claus
Verenzon Bernd
Bischoff Daniel
Derman Georg
Curzer Raimund
Rudolph Claus
Verenzon Bernd
Application Number:
JP2014545271A
Publication Date:
November 24, 2015
Filing Date:
December 07, 2012
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07D401/06; A61K31/4196; A61K31/437; A61K31/444; A61K31/454; A61K31/4725; A61K31/496; A61K31/501; A61K31/517; A61K31/519; A61K31/541; A61K31/55; A61P25/18; A61P25/28; A61P43/00; C07D401/14; C07D403/06; C07D405/14; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D487/04; C07D491/048; C07D495/04; C07D498/04; C07D513/04
Domestic Patent References:
| JP2000507601A | ||||
| JP2007513969A |
Foreign References:
| WO2011082010A1 | ||||
| WO2008156580A1 |
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Maki Kubota
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Maki Kubota