Title:
ＣＮＳ関連疾患を処置するための１，３－ジヒドロ－１，４－ベンゾジアゼピン－２－チオン
Document Type and Number:
Japanese Patent JP7139323
Kind Code:
B2
Abstract:
The present invention provides compounds that are muscarinic M1 receptor positive allosteric modulators (PAM) and useful in the treatment of diseases, mediated by the muscarinic M1 receptor, such as Alzheimer's disease, cognitive impairment, schizophrenia, pain or sleep disorders, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.
Inventors:
Flor, alexander
Application Number:
JP2019522992A
Publication Date:
September 20, 2022
Filing Date:
October 30, 2017
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D243/22; A61K31/5513; A61P25/04; A61P25/18; A61P25/20; A61P25/28; C07D243/14; C07D401/04
Domestic Patent References:
| JP51065787A | ||||
| JP51065800A | ||||
| JP62148488A | ||||
| JP47042696A | ||||
| JP4230280A | ||||
| JP2005525392A |
Foreign References:
| WO2016171470A1 |
Other References:
International Journal of Molecular Sciences,2014年09月05日,Vol.15,No.9,p15741-15753,doi:10.3390/ijms150915741
Chemical and Pharmaceutical Bulletin,1973年,Vol.21,No.11,p2382-2390,doi:10.1248/cpb.21.2382
Journal of Medicinal Chemistry,1971年,Vol.14,No.11,p1078-1081,doi:10.1021/jm00293a015
Chemical and Pharmaceutical Bulletin,1973年,Vol.21,No.11,p2382-2390,doi:10.1248/cpb.21.2382
Journal of Medicinal Chemistry,1971年,Vol.14,No.11,p1078-1081,doi:10.1021/jm00293a015
Attorney, Agent or Firm:
Patent Attorney Corporation Tsukuni