Title:
1,3-DITHIOL-2-YLIDENE DERIVATIVE AND USE THEREOF
Document Type and Number:
Japanese Patent JPS61275274
Kind Code:
A
Abstract:
NEW MATERIAL:A 1,3-dithiol-2-ylidene derivative expressed by formula I (R is 1W2 substitutent groups selected from H, halogen, OH, lower alkyl and lower alkoxy).
EXAMPLE: 2-(1,3-Dithiol-2-ylidene)-1-phenyl-4,4,4-trifluorobutane-1,3-dione.
USE: A remedy for hepatic diseases useful for treating and preventing hepatopathy involving, e.g. hepatic parenchymal cell necrosis.
PREPARATION: A dithiolium salt expressed by formula II (R' is lower alkyl or aralkyl; Q is acid residue) is reacted with a β-diketone expressed by formula III in the presence of a base to afford the aimed compound expressed by formula I.
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Inventors:
YOSHIZAWA JUNJI
TSUCHIYA YOSHIMI
HIRAYAMA YUKIO
SHIMADA KAORU
MINO NOBUYUKI
NAKAMICHI KYOKO
MATSUMOTO IKUO
TSUCHIYA YOSHIMI
HIRAYAMA YUKIO
SHIMADA KAORU
MINO NOBUYUKI
NAKAMICHI KYOKO
MATSUMOTO IKUO
Application Number:
JP29346085A
Publication Date:
December 05, 1986
Filing Date:
December 28, 1985
Export Citation:
Assignee:
BANYU PHARMA CO LTD
International Classes:
A61K31/381; A61K31/385; A61K31/40; A61K31/4025; A61K31/415; A61K31/44; A61K31/4433; A61K31/47; A61K31/495; A61P1/16; C07D333/00; C07D339/00; C07D339/06; C07D409/06; (IPC1-7): A61K31/385; C07D339/06