Title:
[1,4]-ジアゼパン-1-カルボン酸誘導体、それらの製造方法およびタキキニンアンタゴニストとしてのそれらの使用
Document Type and Number:
Japanese Patent JP4336107
Kind Code:
B2
Abstract:
The present invention relates to diazepine derivatives of formula (I) wherein R represents hydrogen or C1-4 alkyl; R1 represents hydrogen or C1-4 alkyl; R2 represents trifluoromethyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy or halogen; R3 represents halogen or C1-4 alkyl; R4 represents hydrogen, halogen, C1-4 alkyl or COR6; R5 represents hydrogen, C1-4 alkyl or R5 together within the R1 represents C3-7 cycloalkyl; R6 represents hydroxy, amino, methylamino, dimethylamino, 5 membered heteroaryl group containing 1 to 3 heteroatoms selected independently from oxygen, sulphur and nitrogen or a 6 membered heteroaryl group containing 1 to 3 nitrogen atoms; m or n are independently zero or an integer from 1 to 3; X and Y are independently NR7 or methylene; provided that when X is NR7, Y is methylene and when X is methylene, Y is NR7; R7 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl; and pharmaceutically acceptable salts and solvates thereof; to process for their preparation and their use in the treatment of condition mediated by tachykinins
Inventors:
Giuseppe Alvaro
Application Number:
JP2002579445A
Publication Date:
September 30, 2009
Filing Date:
April 05, 2002
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
C07D243/08; A61K31/551; A61P1/04; A61P1/08; A61P17/04; A61P17/06; A61P25/04; A61P25/18; A61P25/20; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P37/00; A61P37/08; A61P43/00
Domestic Patent References:
| JP11116557A | ||||
| JP2000506150A |
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga