Title:
1,4-BENZOQUINONE DERIVATIVE, DIBENZOFURAN-1,4-DIONE DERIVATIVE AND ANTITUMOR AGENT
Document Type and Number:
Japanese Patent JPH08301810
Kind Code:
A
Abstract:
PURPOSE: To obtain a new 1,4-benzoquinone derivative which is represented by a specific formula, shows strong cytotoxicity and is useful as an antitumor agent.
CONSTITUTION: The objective compound is represented by formula I (R1 and R2 are each a halogen selected from the group consisting of Cl, Br and I; R3 is an alkyl, a cycloalkylmethyl; R4 is H, methyl), preferably a compound of formula II (R5 is H, an alkyl, a cycloalkylmehyl; R6 and R7 are each H, methyl), for example, 2,3-dichloro-5-methoxy-6-methyl-1,4-benzoquinone. This compound is prepared, for example, by halogenating 2-methoxy-3-methyl-1,4-benzoquinone of formula III with conc. hydrogen halide acid and aqueous hydrogen peroxide in the presence of magnesium halide at 0-30°C.
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Inventors:
TERAJIMA ATSURO
KATO TADASHI
UEKI YASUYUKI
ITO MASANORI
YAMADA KAORU
KATO TADASHI
UEKI YASUYUKI
ITO MASANORI
YAMADA KAORU
Application Number:
JP31781295A
Publication Date:
November 19, 1996
Filing Date:
December 06, 1995
Export Citation:
Assignee:
SAGAMI CHEM RES
International Classes:
C07D307/91; A61K31/12; A61K31/122; A61K31/34; A61K31/343; A61P35/00; C07C50/28; C07C50/30; (IPC1-7): C07C50/28; A61K31/12; A61K31/34; C07C50/30; C07D307/91