NEW MATERIAL:A compound expressed by formula I [R1 and R3 are H or lower alkyl; R2 is lower alkyl; A is 1W10C alkylene; B is CH=CH or C≡C, provided that R3 is not n-butyl when R1 is H or CH3; R2 is CH3; A is (CH2)9 and B is CH=CH (cis)].
EXAMPLE: 2,5-Dimethoxy-3[(Z)-6-undecen-1-yl]-p-benzoquinone.
USE: A 5-lipoxygenase inhibitor, capable of inhibiting formation of slow-reacting substance of anaphylaxis (SRS-A) from arachidonic acid, and useful for preventing and treating asthma, inflammation and allergy, etc., and having various action such as stabilizing biomembranes, amelioration of cerebral circulation, hypotension, immunity enhancement, protection against bacterial infection, etc.
PREPARATION: For example, a compound expressed by formula II (R1' is lower alkyl; E is methoxymethyl) is reacted with a compound expressed by formula III(X is halogen) to give a compound expressed by formula IV, which is then demethoxymethylated and oxidized to afford the corresponding compound expressed by formula I.
FUKUYAMA YOSHIYASU
MATSUI KUNIAKI
| JPS6075442A | 1985-04-27 |
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