Title:
1,4-NAPHTHOQUINONE DERIVATIVE, ITS PREPARATION, AND ITS USE
Document Type and Number:
Japanese Patent JPS56125335
Kind Code:
A
Abstract:
NEW MATERIAL:A 1,4-naphthoquinone derivative of formula I [R1 is H, OH, lower alkoxy, or arylthio; R2 is carboxy, esterified carboxy, or amidated carboxy; or R1 and R2 together form -O-C(=O)-; R3 is H or lower alkyl; R4 is lower alkyl; R5 is H or halogen; R6 is H, lower alkyl, or lower alkanoyl], or its salt at the carboxyl group.
EXAMPLE: 8-Hydroxy-1-methoxy-3-methyl-7,12-dihydro-5H-benzo[d]naphtho [2,3-b] pyran-5,7,12-trione.
USE: Preventive and remedy for coccidiosis.
PROCESS: The compound of formula I' (R1 and R2 particular groups defined in the formula I) is separated from the cultured product obtained by culturing bacteria belonging to Streptomyces genus and capable of producing the compound of formula I', e.g. Streptomyces auranticolor No.5995, in a culturing medium.
Inventors:
IKUSHIMA KOUICHI
TANAKA HIROKAZU
OOE OSAMU
IGUCHI HIDEKO
MUKOUZAKA MASANOBU
AOKI HATSUO
ARAKAWA HIROSHI
IMANAKA HIROSHI
Application Number:
JP2967580A
Publication Date:
October 01, 1981
Filing Date:
March 06, 1980
Assignee:
FUJISAWA PHARMACEUTICAL CO
International Classes:
A61K31/12; A61K31/16; A61K31/165; A61K31/19; A61K31/215; A61K31/22; A61K31/35; A61K31/352; A61K31/365; A61K31/66; A61P33/02; C07C50/10; C07C65/00; C07C65/03; C07C65/105; C07C66/00; C07C67/00; C07C69/02; C07C69/94; C07C69/95; C07C231/00; C07C233/12; C07C235/46; C07C235/84; C07C275/54; C07C313/00; C07C323/22; C07C323/61; C07D311/78; C07F9/38; C07F9/40; C12P7/40; C12P7/66; C12P17/06; C12R1/465; (IPC1-7): A61K31/12; A61K31/16; A61K31/215; A61K31/35; A61K31/365; A61K31/66; C07C65/03; C07C65/24; C07C69/02; C07C103/26; C07C103/76; C07C127/22; C07C149/36; C07D311/78; C07F9/40; C12P7/66; C12R1/465
