１，４−ナフトキノン誘導体およびその治療用途

Japanese Patent JP5725299

B2

1,4 naphthoquinones derivatives, of formula (I) wherein A is selected from the following rings: their preparation and their application as antimalarial agents

JP4060588	Aqueous reaction using star polymer
JPS63501288	[Title of the Invention] All [ 1 and 4-NAFTA range ], 1, 4-hydroquinone derivative
WO/1996/022269	PROCESS FOR PRODUCING QUINONES

Daviau-Charve, Elizabeth
Muller, Tobias
Bower,holger
Schirmer, Earl Heiner

JP2011501210A

May 27, 2015

March 25, 2009

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ECOLE NORMALE SUPERIEURE
Ruprecht-Karls-Universitart Heidelberg

C07C50/10; A61K31/122; A61K31/136; A61K31/192; A61K31/216; A61K31/27; A61K31/275; A61K31/495; A61K45/00; A61P33/06; A61P43/00; C07C43/23; C07C46/00; C07C50/24; C07C50/32; C07C50/38; C07C51/373; C07C66/00; C07C69/95; C07C201/12; C07C205/46; C07C221/00; C07C225/24; C07C233/33; C07C253/30; C07C255/29; C07C255/56; C07D295/08; C07D295/10

WO1999048491A1

HOWLAND JOHN L,INHIBITION OF MITOCHONDRIAL SUCCINATE OXIDATION BY ALKYL HYDROXY NAPHTHOQUINONES,BIOCHIMICA ET BIOPHYSICA ACTA,1965年 1月 1日,V105 N2,P205-213
BAUER, HOLGER,A FLUORO ANALOGUE OF THE MENADIONE DERIVATIVE 6-[2'-(3'-METHYL)-1',4'-NAPHTHOQUINOLYL]以下備考,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2006年,V128 N33,P10784-10794,HEXANOIC ACID IS A SUICIDE SUBSTRATE OF GLUTATHIONE REDUCTASE.
FRIEBOLIN WOLFGANG,ANTIMALARIAL DUAL DRUGS BASED ON POTENT INHIBITORS OF GLUTATHIONE 以下備考,JOURNAL OF MEDICINAL CHEMISTRY,2008年 2月 9日,V51 N5,P1260-1277,REDUCTASE FROM PLASMODIUM FALCIPARUM

Shintaro Nogawa
Masanori Akiyama
Shinji Kai
Yusuke Kaneko
Kiyoshi Inamoto

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