Title:
選択的エストロゲン活性を有する16,17-炭素環縮合ステロイド化合物
Document Type and Number:
Japanese Patent JP5095902
Kind Code:
B2
Abstract:
The invention discloses a steroid compound having the formula (1): wherein dotted bonds represent optional double bonds; R6 is H, ═CH2, or —CH3, or —CH2—CH3; R7 is H, C1-4-alkyl, C2-5 alkenyl or C2-5-alkynyl, wherein the alkyl, alkenyl or alkynyl group may be substituted with 1 to 3 halogen atoms independently chosen from the group of fluorine or chlorine atoms; R11 is H, Cl1-4-alkyl, C2-4-alkenyl, C2-4-alkynyl or C1-4-alkylidene, wherein the alkyl, alkenyl, alkynyl or alkylidene group may be substituted with 1 to 3 halogen atoms independently chosen from the group of fluorine or chlorine atoms; E represents together with carbon atoms 16 and 17 of the steroid skeleton a four to seven-membered ring, said ring being α and in cis-configuration with respect to the steroid skeleton, optionally comprising one or two endocyclic bonds; or a prodrug thereof. Such compounds can be used in therapy and for methods for selective modification of the activity of estrogen receptors.
Inventors:
Rosen, Hiyubert Jan Josef
Application Number:
JP2002505804A
Publication Date:
December 12, 2012
Filing Date:
May 01, 2001
Export Citation:
Assignee:
STICHTING TOP INSTITUTE PHARMA
International Classes:
A61K31/565; A61K31/56; A61P5/30; C07J53/00; A61P5/36; A61P15/12; A61P15/18
Domestic Patent References:
| JP10273499A |
Foreign References:
| US3194821 |
Other References:
Journal of Medicinal Chemistry,1993年,36,2973-2983
J R BULL,JOURNAL OF THE CHEMICAL SOCIETY,英国,CHEMICAL SOCIETY,1997年,P1179-1192
The Journal of Organic Chemistry,1968年,3544-3547
J R BULL,JOURNAL OF THE CHEMICAL SOCIETY,英国,CHEMICAL SOCIETY,1997年,P1179-1192
The Journal of Organic Chemistry,1968年,3544-3547
Attorney, Agent or Firm:
Kawaguchi International Patent Office
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura