PURPOSE: To obtain a new compound having an activity against the cardiovascular system and extremely low in toxicity and useful for treating cardiac and vascular diseases such as heart failure and hypertension.
CONSTITUTION: This compound of formula I [a wave line denotes that 17- positioned substituent can take α or β configuration; Y is O or guanidimide when a linear line at 3-position and a double line of the wave line are double bonded, or Y is OH, OR2 (R2 is H, a 2-6C alkyl or the like) or the like when the double bond is a single bond, can take α or β configuration; R is an aryl ring, or an (un)satd. heterocyclic ring contg. a hetero atom such as O and S, provided that R is not a 3-furyl ring, 4-pyridazinyl ring or the like; R1 is H, methyl or the like], such as 17β-phenyl-5β-androst-15-ene-3β,14β,17α-triol is obtained by reacting an aryl or heterocyclyl organic metal with a compd. of formula II (W is H or a protecting group; Y is Y in formula I other than guanidinoimino, and protected in the case of containing OH or the like).
RUIGI BERUNARUDEI
ARUBERUTO SETSURI
PIERO MEROONI
GURORIA PADOANI
RUIZA KUWADORI
