Title:
17,20(Z)-デヒドロビタミンD類似体およびそれらの使用
Document Type and Number:
Japanese Patent JP5161582
Kind Code:
B2
Abstract:
This invention discloses 17,20(Z)-dehydro vitamin D analogs, and specifically 17(Z)-1α,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also may be used to treat autoimmune disorders and inflammatory diseases in humans as well as renal osteodystrophy and obesity. This compound also has significant calcemic activity making it a therapeutic agent for the treatment or prophylaxis of osteoporosis, osteomalacia, renal osteodystrophy and hypoparathyroidism.
Inventors:
Deluca, Hector Ef
Taddy, Buruli Padmaja
Plum, Lori Ai
Claget-Darm, Margaret
Taddy, Buruli Padmaja
Plum, Lori Ai
Claget-Darm, Margaret
Application Number:
JP2007543268A
Publication Date:
March 13, 2013
Filing Date:
November 18, 2005
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
C07C401/00; A61K31/593; A61P1/04; A61P3/02; A61P3/04; A61P3/06; A61P3/10; A61P11/06; A61P17/06; A61P19/08; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/06; C07F7/18
Domestic Patent References:
| JP2008520690A | ||||
| JP8504746A | ||||
| JP2001519327A | ||||
| JP2001504135A | ||||
| JP2001506610A | ||||
| JP2007512376A |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hirose Shinobu
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hirose Shinobu