Title:
18-メチル-19-ノルアンドロスタ-4-エン17,17-スピロエーテル(18-メチル-19-ノル-20-スピロキサ-4-エン-3-オン)、及びそれを含む医薬品
Document Type and Number:
Japanese Patent JP5326085
Kind Code:
B2
Abstract:
The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I in which Z is an oxygen atom, two hydrogen atoms, a group ═NOR or ═NNHSO2R, where R is a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms, R4 is a hydrogen atom, a halogen atom or a trifluoromethyl group, and R6 and/or R7 may have α or β configuration, and R6 and R7 are independently of one another a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms or a straight- or branched-chain alkenyl group having 2 to 4 or 3 to 4 carbon atoms or a saturated cycloalkyl group having 3 to 5 carbon atoms or together are a methylene group or a double bond. The novel compounds have progestational and antimineralocorticoid activity.
Inventors:
Ballman, Rolf
Kuhnke, Joachim
Huebner, Jan
Gallus, Norbert
Frederik Menges
Bolden, Steffen
Moon, Hans-Peter
Prairie, katoya
Kuhnke, Joachim
Huebner, Jan
Gallus, Norbert
Frederik Menges
Bolden, Steffen
Moon, Hans-Peter
Prairie, katoya
Application Number:
JP2009517034A
Publication Date:
October 30, 2013
Filing Date:
June 29, 2007
Export Citation:
Assignee:
Bayer Intellectual Property GmbH
International Classes:
C07J53/00; A61K31/565; A61K31/58; A61P5/30
Domestic Patent References:
| JP60161997A |
Foreign References:
| US3798213 | ||||
| US6177416 | ||||
| DE3022337A1 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Kenji Chatan
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Kenji Chatan