Title:
19-ノルビタミンD誘導体
Document Type and Number:
Japanese Patent JP4961562
Kind Code:
B2
Abstract:
Disclosed is a 19-norvitamin D derivative which has enhanced pharmacological effects compared with a 1,25-(OH)2D3 derivative and is not accompanied by an adverse side effect of causing hypercalcemia. Also disclosed is a process for producing the derivative. The vitamin D derivative is 16-ene-22-thio-19-norvitamin D having all of the following three partial structures: (1) the introduction of a hetero atom (e.g., an oxygen or sulfur atom) into position 22 of the side chain in the vitamin D; (2) the introduction of a double bond into 16-17 positions of the D ring moiety; and (3) the removal of a 19-exomethylene group. Because this derivative is improved in transcription activity, osteoclast differentiation promoting activity, and activity of suppressing the differentiation into mature dendritic cells, it can be used as a therapeutic agent for osteoporosis, an autoimmune disease, rachtis or osteomalacia or a carcinostatic agent.
Inventors:
Masato Shimizu
Application Number:
JP2007506036A
Publication Date:
June 27, 2012
Filing Date:
March 03, 2006
Export Citation:
Assignee:
Tokyo Medical And Dental University, Medical Hospital
International Classes:
C07C401/00; A61K31/59; A61P3/02; A61P19/08; A61P19/10; A61P35/00; A61P37/02; C07B53/00; C07B57/00
Domestic Patent References:
| JP2002537222A | 2002-11-05 | |||
| JP2001515881A | 2001-09-25 | |||
| JPH10231284A | 1998-09-02 |
Foreign References:
| WO2001096293A1 | 2001-12-20 | |||
| WO2001079166A1 | 2001-10-25 |
Attorney, Agent or Firm:
Masayuki Masabayashi