Title:
１Ｄ０５ＰＣＳＫ９拮抗薬
Document Type and Number:
Japanese Patent JP5775308
Kind Code:
B2
Abstract:
Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
Inventors:
Kondra, Jiyoung H
Cabo, Rose M
Hammond, Holly A
Orsatstay, Laura
Pandate, Silpa
Peterson, Lawrence Bee
Santoro, Joseph Sea
Citlanie, Aishiya
Utd, Dana Day
Henrik Matsuha
Yodel, highday
Gregory, Sonia M
Blue, jeffrey tay
One, kevin
Luo, Peter
Dennis Kay, Nowlotsky
Jiyoung, Pinyu
Thong, Huong
Li, Yang
Cabo, Rose M
Hammond, Holly A
Orsatstay, Laura
Pandate, Silpa
Peterson, Lawrence Bee
Santoro, Joseph Sea
Citlanie, Aishiya
Utd, Dana Day
Henrik Matsuha
Yodel, highday
Gregory, Sonia M
Blue, jeffrey tay
One, kevin
Luo, Peter
Dennis Kay, Nowlotsky
Jiyoung, Pinyu
Thong, Huong
Li, Yang
Application Number:
JP2010546034A
Publication Date:
September 09, 2015
Filing Date:
February 06, 2009
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
A61K39/395; A61K45/00; A61K48/00; A61P3/06; A61P9/00; A61P43/00
Other References:
JCI,Vol.116,No.11(2006)p.2995-3005(with Supplement)
BBA,Vol.1781(2008)p.184-191(Available Online Feb.2,2008)
JMB,Vol.296(2000)p.57-86
BBA,Vol.1781(2008)p.184-191(Available Online Feb.2,2008)
JMB,Vol.296(2000)p.57-86
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama