PURPOSE: To produce the new compd. useful as neuroprotective agents.
CONSTITUTION: This compd. is expressed by formula I [X is H, Cl, Br, F, OH, (aryl) lower alkoxy or the like; Y is H, lower alkyl, Cl or Br; Z is H, lower alkyl, lower alkoxy, halogen or the like; R1 is H, (aryl) lower alkyl or the like; R2 is H, (hydroxy) lower alkyl; R3 is H, lower alkyl, R2 and R3 together with the carbon to which they are attached form 3-7C cycloalkyl; R4 is H or lower alkyl; R5 is H, lower alkyl, aryl, acyl or the like; R6 is H, Cl, Br, arylcarbonyl or the like; and (m) and (n) are 0 to 5, and m+n<5] such as [N-(1H-indol-1-yl)-2-amino]acetamide hydrochloride. The compd. of formula I is obtd. by allowing the aminoindol of formula II to react with the compd. of formula III (R7 is lower alkyl or the like) in the presence of a condensing agent such as dicyclohexylcarbodiimide, and the product is deprotected.
Flanagan, Denise M.
Martin, Lawrence L.
Nemoto, Peter A.
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