Title:
2-アミノ-2-フェニル-アルカノール誘導体、それらの製造、及びそれらを含む医薬組成物
Document Type and Number:
Japanese Patent JP5497665
Kind Code:
B2
Abstract:
2-amino-2-phenyl-alkanol ester derivatives of general formula (I) in which: R1 is H, straight or branched 1 to 4C alkyl, straight or branched 2 to 4C alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, R2 is a —CO—R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or R2 is a —CO—Y—R4 radical for which Y is —O—, —S—, —NH—, -Nalk- for which alk is straight or branched (1 to 4C) alkyl, and R4 is alkyl, aryl, aralkyl or heterocyclylalkyl, capable of being substituted by one or more halogen atoms or OH radicals, straight or branched (1 to 4C) alkyl, alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino (1 to 4C) straight or branched, or oxo, or capable of being substituted by R5COO— in which R5 is alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by an amino acid residue, or represents an heterocyclyl radical, or R2 is alkyl (2 to 4C) substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5- or 6-member heterocycle optionally having another heteroatom (O or N), or substituted by alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, it being understood that said straight or branched substituted alkyl radical comprises at least 2C between >N—R2 and the substituent; and R3 is alkyl (1 to 4C) straight or branched unless specifically mentioned, alkyl or acyl are straight or branched (1 to 7C), in their R or S forms or their mixtures, as well as their pharmaceutically acceptable salts when these exist.
Inventors:
Denny, Alexi
Pacho Jean
Dini, Christoph
Pacho Jean
Dini, Christoph
Application Number:
JP2010544757A
Publication Date:
May 21, 2014
Filing Date:
January 30, 2009
Export Citation:
Assignee:
Oroxel
Denny, Alexi
Denny, Alexi
International Classes:
C07C219/14; A61K31/27; A61K31/4406; A61P29/00; C07C213/06; C07C269/04; C07C269/06; C07C271/16; C07C271/22; C07C271/48; C07C333/04; C07D213/82
Domestic Patent References:
| JP2009539777A | ||||
| JP2003518497A |
Foreign References:
| GB1434826B | ||||
| WO2005012248A1 |
Other References:
Martin, Arnaud et al.,Synthesis of 2-(methylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate, the main bioactive metabolite of trimebutine maleate,ARZNEIMITTEL-FORSCHUNG,2000年,50(6),544-549
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Takahide Sasaki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Takahide Sasaki