2-シアノプロパン酸アミドおよびエステル誘導体ならびにそれらの使用法。

Title:

2-シアノプロパン酸アミドおよびエステル誘導体ならびにそれらの使用法。

Document Type and Number:

Japanese Patent JP2006526630

Kind Code:

A

Abstract:

This invention provides compounds of formula I or a pharmaceutically acceptable salt thereof that are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.

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Inventors:

Thomas Jay Cuggiano
Antony A. Brazeil
William Jay Moore
Karan Yongae Kim

Application Number:

JP2006514164A

Publication Date:

November 24, 2006

Filing Date:

April 30, 2004

Export Citation:

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Assignee:

Wyeth

International Classes:

C07C255/41; A61K31/277; A61K31/395; A61K31/397; A61K31/404; A61K31/437; A61K31/438; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/4439; A61K31/444; A61K31/4453; A61K31/45; A61K31/451; A61K31/454; A61K31/47; A61K31/4709; A61K31/472; A61K31/495; A61K31/496; A61K31/497; A61K31/506; A61K31/5375; A61K31/5377; A61K31/54; A61K31/55; A61P1/04; A61P1/16; A61P3/06; A61P3/10; A61P3/14; A61P7/00; A61P7/02; A61P7/04; A61P9/00; A61P9/04; A61P9/10; A61P9/14; A61P13/08; A61P13/12; A61P15/08; A61P15/10; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P25/18; A61P25/20; A61P25/22; A61P25/28; A61P27/02; A61P27/12; A61P29/00; A61P31/04; A61P35/00; A61P35/02; A61P37/02; C07C255/19; C07C255/43; C07C323/62; C07D205/04; C07D207/27; C07D209/08; C07D209/14; C07D211/18; C07D211/32; C07D211/34; C07D211/52; C07D211/58; C07D211/70; C07D211/74; C07D211/82; C07D213/57; C07D213/74; C07D215/00; C07D215/14; C07D217/06; C07D217/16; C07D223/04; C07D239/42; C07D241/20; C07D265/30; C07D295/14; C07D295/18; C07D295/185; C07D295/192; C07D295/20; C07D307/68; C07D401/04; C07D401/10; C07D401/12; C07D401/14; C07D471/04; C07D471/10; C07D491/113; A61K

Domestic Patent References:

JPH08268909A	1996-10-15
JP2001513501A	2001-09-04

Foreign References:

WO2005039581A1	2005-05-06
WO2005039582A1	2005-05-06
WO2005039583A1	2005-05-06

Other References:

JPN6010048661, Ａｎｔｉ−Ｃａｎｃｅｒ　Ｄｒｕｇ　Ｄｅｓｉｇｎ, 1996, １１（６）, ｐ．４６３−４８３
JPN6010048662, Ｅｇｙｐｔｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃｈｅｍｉｓｔｒｙ, 1974, １７（６）, ｐ．８７９−８８７
JPN6010048663, Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ, 1974, ９（４）, ｐ．４６２−４６４

Attorney, Agent or Firm:

Mitsuo Tanaka
Tadayuki Motoyama
Kenji Tomita

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