Title:
2-シアノピロリジン誘導体および薬剤としてのそれらの使用
Document Type and Number:
Japanese Patent JP2004503531
Kind Code:
A
Abstract:
The present invention relates to certain N-(substituted glycyl)-2-cyanopyrrolidines of formula (I) wherein Y is as defined herein, in free form or in acid addition salt form. Compounds of formula (I) inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.
Inventors:
Edwin Bernard Bihlhower
Application Number:
JP2002510439A
Publication Date:
February 05, 2004
Filing Date:
June 11, 2001
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
A61K31/40; A61K31/427; A61K31/428; A61K31/4439; A61K31/454; A61K31/506; A61P3/04; A61P3/08; A61P3/10; A61P19/02; A61P19/10; A61P43/00; C07D207/16; C07D401/12; C07D403/12; C07D409/12; C07D417/12; C07D417/14; (IPC1-7): C07D207/16; A61K31/40; A61K31/427; A61K31/428; A61K31/4439; A61K31/454; A61K31/506; A61P3/04; A61P3/08; A61P3/10; A61P19/02; A61P19/10; A61P43/00; C07D401/12; C07D403/12; C07D409/12; C07D417/12; C07D417/14
Domestic Patent References:
| JP2003535034A | 2003-11-25 |
Foreign References:
| WO1998019998A2 | 1998-05-14 | |||
| US6011155A | 2000-01-04 |
Attorney, Agent or Firm:
Aoyama Aoi
Osamu Kawamiya
Kazuaki Kojima
Mitsutaka Iwasaki
Osamu Kawamiya
Kazuaki Kojima
Mitsutaka Iwasaki