HSP70誘発因子としての2-プロペン-1-オン

Title:

HSP70誘発因子としての2-プロペン-1-オン

Document Type and Number:

Japanese Patent JP4790704

Kind Code:

B2

Abstract:

The present invention relates to novel compounds of 2-propene-1-one series, of general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, wherein R₅, R₆, Q and Y are as defined in the specification. The present invention also relates to a process for preparing such compounds, compositions containing such compounds, and use of such compound and composition in medicine. The compounds of the general formula (I) induce HSP-70 and are useful for the treatment of diseases accompanying pathological stress in a living mammalian organism, including a human being, such as stroke, myocardial infarction, inflammatory disorder, hepatotoxicity, sepsis, diseases of viral origin, allograft rejection, tumourous diseases, gastric mucosal damage, brain haemorrhage, endothelial dysfunctions, diabetic complications, neuro-degenerative diseases, post-traumatic neuronal damage, acute renal failure, glaucoma and aging related skin degeneration.

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Inventors:

Kumar, Prab Hut
Manet, Utta Murajaram
Gupta, Ramesh Chandra
Nadkarni, Sunil Sadanand
Mohanan, Anoka
Tandon, Lucci
Munshi, Cillary

Application Number:

JP2007507931A

Publication Date:

October 12, 2011

Filing Date:

April 11, 2005

Export Citation:

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Assignee:

TORRENT PHARMACEUTICALS LIMITED

International Classes:

C07D213/71; A61K9/08; A61K9/10; A61K9/14; A61K9/20; A61K9/48; A61K31/4402; A61K31/4406; A61K31/4439; A61K31/444; A61K31/4709; A61K31/496; A61K31/4965; A61K31/498; A61K31/4985; A61K31/5377; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P13/12; A61P17/16; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/06; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/06; C07D213/72; C07D213/74; C07D213/75; C07D215/14; C07D215/42; C07D241/12; C07D241/18; C07D241/42; C07D241/44; C07D401/04; C07D401/08; C07D401/10; C07D401/14; C07D403/10; C07D403/12; C07D405/12; C07D409/10; C07D409/12; C07D409/14; C07D413/12; C07D417/04

Foreign References:

WO2000018390A1	2000-04-06
US20060235073A1	2006-10-19

Attorney, Agent or Firm:

Narumi Morishima

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