Title:
2-プロピリデン-19-ノル-ビタミンD化合物
Document Type and Number:
Japanese Patent JP5005340
Kind Code:
B2
Abstract:
2-propylidene-19-nor-vitamin D compounds are disclosed as well as pharmaceutical uses for these compounds and methods of synthesizing these compounds. These compounds are characterized by high bone calcium mobilization activity and high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment and prophylaxis of diseases where bone formation is desired, particularly osteoporosis, as well as autoimmune diseases such as multiple sclerosis, diabetes mellitus and lupus. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. These compounds also increase both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.
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| WO/1999/018070 | NOVEL VITAMIN D ANALOGUES |
| WO/2020/014776 | CANNABINOID ORAL DISPERSIBLE FILM STRIP |
Inventors:
Deluca, Hector Ef
Rafal Earl
Grebocca, Agneska
Plum, Lori Ai
Rafal Earl
Grebocca, Agneska
Plum, Lori Ai
Application Number:
JP2006509883A
Publication Date:
August 22, 2012
Filing Date:
April 09, 2004
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
C07C401/00; A61K31/593; A61P1/00; A61P1/04; A61P3/10; A61P9/12; A61P11/06; A61P13/08; A61P17/02; A61P17/06; A61P17/14; A61P19/00; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/06; C07C35/21; C07F7/18; C07D307/00
Domestic Patent References:
| JP2001504135A | ||||
| JP6321894A | ||||
| JP6041059A | ||||
| JP61267549A |
Foreign References:
| WO2001074766A1 | ||||
| WO1996001811A1 |
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri