Title:
好中球エラスターゼインヒビターとしての2-ピリジン誘導体
Document Type and Number:
Japanese Patent JP2008533137
Kind Code:
A
Abstract:
The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
Inventors:
Thomas Brimato
Carolina Lavitz
Hans Ren
Antonio Nikitidis
Asim Kumar Ray
Yenny Sandmark
Carolina Lavitz
Hans Ren
Antonio Nikitidis
Asim Kumar Ray
Yenny Sandmark
Application Number:
JP2008501840A
Publication Date:
August 21, 2008
Filing Date:
March 14, 2006
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D213/82; A61K31/4412; A61K31/4436; A61K31/4439; A61K31/444; A61K31/5377; A61P1/04; A61P9/10; A61P11/00; A61P11/06; A61P19/02; A61P27/16; A61P29/00; A61P35/00; A61P43/00; C07D401/12; C07D409/12
Domestic Patent References:
| JP2001518081A | 2001-10-09 |
Foreign References:
| WO2004043924A1 | 2004-05-27 | |||
| WO2005021509A1 | 2005-03-10 | |||
| WO2004020410A2 | 2004-03-11 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Takuji Yamada
Mitsutaka Iwasaki