NEW MATERIAL:A compound expressed by formula I [R1 is H or methyl; R2 to R4 are H, lower alkyl, aminocarbonyl, lower alkoxy(carbonyl), cyano or nitro (except that all the R2 to R4 are H or lower alkyl)].
EXAMPLE: (5R,6S)-2-(trans-2-Carbamoylvinyl)-6-[(1R)-1-hydroxyethyl]-1carbapen-2- em-3-carboxylic acid.
USE: Useful as an antimicrobial agent having powerful antimicrobial activity against sensitive and tolerant Gram-positive and Gram-negative bacteria and excellent stability to β-lactamases and DHP-1 with excellent oral absorbability.
PREPARATION: A compound expressed by formula II (R5 is carboxyl-protecting group; R6 is H or OH-protecting group; Tf is trifluoromethanesulfonyl) is reacted with a compound expressed by formula III in the presence of a Pd compound and a salt and the protecting groups, as necessary, are then removed.
KATO YOSHIAKI
FUKATSU HIROSHI
