Title:
2-ARYL-BENZIMIDAZOLE-5-CARBOXAMIDE DERIVATIVE
Document Type and Number:
Japanese Patent JP2009001495
Kind Code:
A
Abstract:
To provide a 2-aryl-benzimidazole derivative which can inhibit an sEH (soluble epoxide hydrolase) activity to increase EETs (epoxyeicosatrienoic acids) and is expected as a medicine for circulatory organ diseases including hypertension, cerebral infarction, and renal diseases, based on a vasodilator action, a series of inflammatory diseases via an NFB/IB kinase activation, autoimmune diseases, endocrine metabolic diseases including hyperlipemia and diabetes, and adult respiratory distress syndromes.
This compound is a 2-aryl-benzimidazole derivative represented by formula of Fig. a pharmaceutically acceptable salt or its hydrate.
Inventors:
OTA TOMOKI
HIRANO HITOMI
KAKINUMA HIROYUKI
BUSUJIMA TAKESHI
HIRANO HITOMI
KAKINUMA HIROYUKI
BUSUJIMA TAKESHI
Application Number:
JP2005299464A
Publication Date:
January 08, 2009
Filing Date:
October 13, 2005
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD
International Classes:
C07D235/08; A61K31/4184; A61K31/427; A61K31/439; A61K31/454; A61K31/4709; A61K31/497; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61P9/10; A61P9/12; A61P13/12; A61P43/00; C07D235/18; C07D401/12; C07D403/12; C07D405/04; C07D405/06; C07D405/12; C07D409/04; C07D409/06; C07D409/14; C07D413/12; C07D417/12; C07D417/14; C07D453/02
Attorney, Agent or Firm:
Sotori Soichi