Title:
2 for the disposal of a CNS obstacle - oxo -- 2 and 3-dihydroIndore
Document Type and Number:
Japanese Patent JP6116693
Kind Code:
B2
Abstract:
The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula wherein is phenyl or a heteroaryl group, selected from pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl or pyrazolyl; is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be on all free positions; R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or halogen; n is 1 or 2; if n is 2, R1 may be the same or not; R2/R2′ are independently from each other lower alkyl, or form together with the carbon atom to which they are attached a C3-6-cycloalkyl ring; R3 is lower alkyl, C3-6-cycloalkyl, CH2—C3-6-cycloalkyl, C3-6-cycloalkyl wherein one ring-carbon atom is replaced by —O—, (CH2)3—O—C3-6-cycloalkyl, lower alkyl substituted by hydroxy, lower alkyl substituted by halogen, (CH2)3—S(O)2—C3-6-cycloalkyl or (CH2)2—S(O)2-lower alkyl; R4 is hydrogen, halogen or lower alkyl; m is 1 or 2; if m is 2, R4 may be the same or not; as well as with a pharmaceutically acceptable salts thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.
Inventors:
Bruner, Daniela
Marberg, Jessica
Shankar, Bhavani Gee
Korzewski, Sabine
Limberg, Anya
Erich Prinzen
Reamel, claus
Stol, Theodor
Marberg, Jessica
Shankar, Bhavani Gee
Korzewski, Sabine
Limberg, Anya
Erich Prinzen
Reamel, claus
Stol, Theodor
Application Number:
JP2015531533A
Publication Date:
April 19, 2017
Filing Date:
September 10, 2013
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D209/34; A61K31/135; A61K31/137; A61K31/138; A61K31/165; A61K31/19; A61K31/197; A61K31/343; A61K31/381; A61K31/404; A61K31/4178; A61K31/437; A61K31/4439; A61K31/444; A61K31/4525; A61K31/496; A61K31/506; A61K31/519; A61K31/55; A61K31/551; A61K31/5513; A61K31/5517; A61K45/00; A61P19/02; A61P25/00; A61P25/04; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P29/00; A61P43/00; C07D401/12; C07D403/12; C07D405/14; C07D471/04
Domestic Patent References:
| JP2010535172A |
Foreign References:
| WO2004110986A1 | ||||
| WO2007063925A1 | ||||
| WO2010123139A1 | ||||
| WO1991001986A1 |
Attorney, Agent or Firm:
Patent business corporation Tsukuni
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