Title:
2-イミノピロリジン誘導体
Document Type and Number:
Japanese Patent JP3795458
Kind Code:
B2
Abstract:
The present invention relates to a 2-iminopyrrolidine derivative selected from the group consisting of 1-(3-tert-butyl-4-methoxy-5-morpholino-phenyl)-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-ethanone; 1-{3-tert-butyl-5-[4-(2-hydroxy-acetyl)piperazin-1-yl]-4-methoxyphenyl}-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-diyhdro-isoindol-2-yl)-ethanone; ethyl (4-{3-tert-butyl-5-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-acetyl]-2-methoxy-phenyl}piperazin-1-yl)-acetate; 1-(3-tert-butyl-4-methoxy-5-piperazin-1-yl-phenyl)-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-ethanone, and (4-{3-tert-butyl-5-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-acetyl]-2-methoxy-phenyl}-piperazin-1-yl)-acetic acid; and salts thereof.
Inventors:
Shuichi Suzuki
Makoto Kotake
Mitsuaki Miyamoto
Tetsuya Kawahara
Shoji Kajiwara
Hishinuma Uharu
Kazuo Okano
Shuhei Miyazawa
Clark richard
Fumihiro Ozaki
Nobuaki Sato
Masanobu Shinoda
Atsushi Kamata
Takashi Tsukada
Fumiyoshi Matsuura
Yoshimitsu Naoe
Taro Terauchi
Yoshiaki Ohashi
Osamu Ito
Hiromu Tanaka
Warrior Takashi
Motoharu Kogushi
Kawada Riki
Toshiyuki Matsuoka
Kobayashi Hiroko
Kenichi Chiba
Kimura Akibun
Naoto Ono
Makoto Kotake
Mitsuaki Miyamoto
Tetsuya Kawahara
Shoji Kajiwara
Hishinuma Uharu
Kazuo Okano
Shuhei Miyazawa
Clark richard
Fumihiro Ozaki
Nobuaki Sato
Masanobu Shinoda
Atsushi Kamata
Takashi Tsukada
Fumiyoshi Matsuura
Yoshimitsu Naoe
Taro Terauchi
Yoshiaki Ohashi
Osamu Ito
Hiromu Tanaka
Warrior Takashi
Motoharu Kogushi
Kawada Riki
Toshiyuki Matsuoka
Kobayashi Hiroko
Kenichi Chiba
Kimura Akibun
Naoto Ono
Application Number:
JP2002583382A
Publication Date:
July 12, 2006
Filing Date:
April 19, 2002
Export Citation:
Assignee:
EISAI CO.,LTD.
International Classes:
C07D209/44; A61K31/403; A61K31/4035; A61K31/4178; A61K31/4184; A61K31/422; A61K31/437; A61K31/454; A61K31/496; A61K31/5377; A61K31/538; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P19/10; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C07D207/22; C07D207/24; C07D207/263; C07D207/267; C07D207/34; C07D209/52; C07D209/54; C07D209/62; C07D209/96; C07D213/73; C07D213/74; C07D233/46; C07D233/66; C07D233/88; C07D233/90; C07D235/30; C07D249/14; C07D261/14; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D403/04; C07D403/06; C07D403/10; C07D403/12; C07D405/06; C07D409/04; C07D409/06; C07D409/10; C07D413/06; C07D413/10; C07D413/12; C07D413/14; C07D417/06; C07D417/10; C07D471/04; C07D487/04; C07D491/10; C07D498/04; C07D521/00; C07D207/26; A61K; A61P; C07D
Domestic Patent References:
| JP4244083A | ||||
| JP8225753A | ||||
| JP51125071A | ||||
| JP51022720A |
Foreign References:
| WO1996005192A1 | ||||
| WO1983002920A1 |
Other References:
Arzneim.-Forsch.,1980年,Vol.30, No.9,p.1487-1493
Chem.Pharm.Bull.,1985年,Vol.33, No.10,p.4564-4571
Heterocycles,1984年,Vol.22, No.12,p.2725-2728
Chemical Abstracts,1973年,Vol.78,p.478,abstract no.111229
J.Chem.Soc.,Chem.Commun.,1984年,No.17,p.1165-1166
Pharmazie,1993年,Vol.48, No.11,p.812-816
Chem.Pharm.Bull.,1985年,Vol.33, No.10,p.4564-4571
Heterocycles,1984年,Vol.22, No.12,p.2725-2728
Chemical Abstracts,1973年,Vol.78,p.478,abstract no.111229
J.Chem.Soc.,Chem.Commun.,1984年,No.17,p.1165-1166
Pharmazie,1993年,Vol.48, No.11,p.812-816
Attorney, Agent or Firm:
Yoshiki Hasegawa
Shiro Terasaki
Shiro Terasaki