Title:
2-methylene vitamin D similar objects and those use
Document Type and Number:
Japanese Patent JP6072811
Kind Code:
B2
Abstract:
This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-vitamin D3 and (20R)-25-hydroxy-2-methylene-vitamin D3, as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also have relatively high calcemic activities evidencing use in the treatment of bone diseases.
Inventors:
Deluca Hector F.
Plum Lori. A.
Shishinski Rafar Earl.
Sibirska Isabella
Plum Lori. A.
Shishinski Rafar Earl.
Sibirska Isabella
Application Number:
JP2014537107A
Publication Date:
February 01, 2017
Filing Date:
October 09, 2012
Export Citation:
Assignee:
Wisconsin Alumni Research Foundation
International Classes:
C07C401/00; A61K31/593; A61P3/02; A61P19/08; A61P19/10; A61P35/00; C07C35/18; C07F7/18
Domestic Patent References:
| JP2010536866A | ||||
| JP2001504135A | ||||
| JP61267549A | ||||
| JP2004512276A | ||||
| JP2005513066A | ||||
| JP2005523906A |
Foreign References:
| US20110082121 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto