Title:
2-NITROIMIDAZOLES AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS5711969
Kind Code:
A
Abstract:
2-Nitroimidazoles having filaricidal activity of the formula I wherein A is one of the groups -C(R3)=C(R1)(R2),-CHBr-CH2Br or -CH2-CCl=CH2; n is 1, 2, 3 or 4; R1 and R2 are hydrogen or C1-3-alkyl and R3 is hydrogen, C1-3-alkyl, chlorine or bromine, and processes for their preparation are described. The compounds of formula I and compounds of formula VII wherein R4 is -CH2-CH2OH, -CH2-CHOH-CH2OCH3, -CH2-CHOH-CH2OH or are useful in the treatment of filariasis is also described.
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Inventors:
BEANAA HOOFUHAINTSU
HARO SHIYUTOORAA
HARO SHIYUTOORAA
Application Number:
JP7026981A
Publication Date:
January 21, 1982
Filing Date:
May 12, 1981
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
C07D233/92; A61K31/415; A61P33/10; C07D233/91; (IPC1-7): A61K31/415; C07D233/91
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