Title:
2-アルキルピペリジンMGLUR5受容体モジュレーター
Document Type and Number:
Japanese Patent JP2012524798
Kind Code:
A
Abstract:
The present invention is directed to 2-alkylpiperidines which are positive allosteric modulators of metabotropic glutamate receptors, particularly the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
Inventors:
Mercer, Swatapee
Loetzker, Anthony J.A.
Williams, Teresa
Ji Yang, Xiu Juan
Loetzker, Anthony J.A.
Williams, Teresa
Ji Yang, Xiu Juan
Application Number:
JP2012507371A
Publication Date:
October 18, 2012
Filing Date:
April 22, 2010
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07D413/04; A61K31/454; A61K31/4545; A61P25/00; A61P25/18; C07D413/14
Domestic Patent References:
| JP2007510713A | 2007-04-26 | |||
| JP2008540634A | 2008-11-20 | |||
| JP2008540635A | 2008-11-20 | |||
| JP2008540636A | 2008-11-20 | |||
| JP2008540637A | 2008-11-20 |
Foreign References:
| WO2008056259A2 | 2008-05-15 |
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama