Title:
2-PYRIDINYLGUANIDINE-BASED UROKINASE INHIBITOR
Document Type and Number:
Japanese Patent JP3521347
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a new 2-pyridinylguanidine-based urokinase inhibitor composed of a specific pyridine derivative, having selectivity to urokinase, free from the problem of thrombogenesis and useful as a reversible competitive inhibitor for urokinase activity.
SOLUTION: The objective compound is expressed by formula I (R1 is H, a halogen, CN or the like; R2 and R3 are each H, a halogen, a (halogenated)1-6C alkyl or the like; R4 is N=C(NH2)2 or NHC(=NH)NH2), e.g. N"-(5-methyl-2- pyridinyl)guanidine. The compound of formula I can be produced e.g. by reacting a corresponding compound of formula II with NH2CN, etc. The compound can be used for angiogenesis, osteoanagenesis, etc., and the administration dose for oral or parenteral administration is preferably 0.5-5 mg/kg.
Inventors:
Barber, Christopher Gordon
Dickinson, Roger Peter
Dickinson, Roger Peter
Application Number:
JP2000104725A
Publication Date:
April 19, 2004
Filing Date:
April 06, 2000
Export Citation:
Assignee:
PFIZER INC
International Classes:
A61K31/44; A61K31/4402; A61K31/4409; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/444; A61K31/4545; A61K31/5377; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P27/02; A61P35/04; A61P43/00; C07D213/73; C07D213/74; C07D213/75; C07D213/81; C07D401/06; C07D405/06; (IPC1-7): C07D213/74; C07D213/73; C07D213/81; C07D401/06; C07D405/06
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