2-SUBSTITUTED ALKYL-3-CARBOXY CARBAPENEMS AS ANTIBIOTICS AND PROCESS FOR PRODUCING THE SAME

Title:

2-SUBSTITUTED ALKYL-3-CARBOXY CARBAPENEMS AS ANTIBIOTICS AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

Japanese Patent JPH04234885

Kind Code:

A

Abstract:

PURPOSE: To provide the novel compd. which is useful as antibiotics and β- lactamase inhibitors.

CONSTITUTION: This compd. is expressed by formula I (R1 is H methyl, etc.; R2 is H, 1 to 6C alkyl, etc.; R3 is H, methoxymethyl, etc.; X is F, Cl, etc.; Y is COOH, SO2, etc.); for example, [5R-[5α,6α(R*)]]-3-[[(2,4-difluorophenyl) sulfonyl]methylene-6-[1-[[(1,1-dimethylentyl)dimethylsillyl]oxy]ethyl]-7-oxo-1- azabicyclo[3,2,0]hept-2-en-2-carboxylic acid. The compd. is obtd. by bringing the tetra substd. allyl azethidine compd. of formula II (Q is an elimination group) into reaction with a nonaqueous base [e.g.; lithium(trimethnylsillyl)amide] at -90 to 20°C in an anhydrous inert non-protonic solvent. The compd. of the formula II is obtd. by using the compd. of formula III (M is metal) as a starting material.

Inventors:

KAARU BII JIIGURAA JIYUNIA
UIRIAMU BUI KARAN
GURETSUGU FUEIJIERUSON

Application Number:

JP10206091A

Publication Date:

August 24, 1992

Filing Date:

April 05, 1991

Export Citation:

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Assignee:

AMERICAN CYANAMID CO

International Classes:

A61K31/397; A61P31/04; C07D205/08; A61K31/40; C07D477/00; C07D477/14; C07D477/18; (IPC1-7): A61K31/40; C07D205/08; C07D477/00

Attorney, Agent or Firm:

Heikichi Odashima

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