Title:
2-置換複素環式化合物および多剤耐性を治療することにおけるそれらの使用
Document Type and Number:
Japanese Patent JP4338970
Kind Code:
B2
Abstract:
Compounds, compositions, and methods for treating multidrug resistance are disclosed. Suitable compounds are 2-substituted heterocyclic compounds. An example compound has the formula:
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Inventors:
Charles Raymond Degenhardt
David Joseph Eikof
David Joseph Eikof
Application Number:
JP2002536052A
Publication Date:
October 07, 2009
Filing Date:
October 16, 2001
Export Citation:
Assignee:
H. Remofit Cancer Center and Research Institute, Inc.
International Classes:
C07D401/14; A61K9/08; A61K9/48; A61K31/4709; A61K31/496; A61P31/04; A61P31/12; A61P35/00; A61P39/00; A61P43/00; C07C51/06; C07C211/27; C07C237/06; C07C237/24; C07C271/22; C07D207/16; C07D211/58; C07D211/60; C07D211/62; C07D213/30; C07D213/56; C07D213/78; C07D215/20; C07D215/233; C07D239/06; C07D263/06; C07D263/12; C07D295/15; C07D295/205; C07D401/06; C07D401/12; C07D405/12; C07D215/22
Domestic Patent References:
| JP9012577A | ||||
| JP6506450A | ||||
| JP8501573A | ||||
| JP4283561A | ||||
| JP6510017A | ||||
| JP5148204A | ||||
| JP3101662A | ||||
| JP6211664A | ||||
| JP2000507578A | ||||
| JP2003529584A | ||||
| JP2003522767A |
Foreign References:
| WO2000050418A1 | ||||
| WO2000032588A1 | ||||
| WO2000001714A1 | ||||
| WO1999000387A1 | ||||
| WO2000018733A1 | ||||
| WO2000018735A1 |
Other References:
Stereoselective synthesis of dolastatin 10 and its congeners,Tetrahedron,1993年,Vol.49, No.9,pp.1913-24
Hall, Iris H.,Substituted 4-hydroxyproline di- and tri-peptides as cytotoxic agents,Amino Acids,1999年,Vol.16, No.1,pp.79-89
Mallams, Alan K.,Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H- 1-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine,Journal of Medicinal Chemistry,1998年,Vol.41, No.6,pp.877-893
Braun, Peter,Effects of glycosylation on fragments of tumor associated human epithelial mucin MUC1,Bioorganic & Medicinal Chemistry,1998年,Vol.6, No.9,pp.1531-1545
Kast, W. Martin,Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes,Cell (Cambridge, MA, United States),1989年,Vol.59, No.4,pp.603-14
Suzuki,Tsuneji,Structure-Activiry Relationship of Newly Synthesized Quinoline derivarives for Reversal of Multidrug Resistance in Cancer,Journal of Medicinal Chemistry,1997年,Vol.40,No.13,pp.2047-2052
Hall, Iris H.,Substituted 4-hydroxyproline di- and tri-peptides as cytotoxic agents,Amino Acids,1999年,Vol.16, No.1,pp.79-89
Mallams, Alan K.,Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H- 1-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine,Journal of Medicinal Chemistry,1998年,Vol.41, No.6,pp.877-893
Braun, Peter,Effects of glycosylation on fragments of tumor associated human epithelial mucin MUC1,Bioorganic & Medicinal Chemistry,1998年,Vol.6, No.9,pp.1531-1545
Kast, W. Martin,Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes,Cell (Cambridge, MA, United States),1989年,Vol.59, No.4,pp.603-14
Suzuki,Tsuneji,Structure-Activiry Relationship of Newly Synthesized Quinoline derivarives for Reversal of Multidrug Resistance in Cancer,Journal of Medicinal Chemistry,1997年,Vol.40,No.13,pp.2047-2052
Attorney, Agent or Firm:
Yoshikazu Tani
Kazuo Abe
Kazuo Abe