Title:
2-VINYL PENAMS AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPS63185393
Kind Code:
A
Abstract:
6 beta -(L- alpha -Aminoadipoyl)-2 alpha -vinyl-2 beta -methylpenam-3-carboxylic acid is provided in an enzymatic process converting delta -(L- alpha -aminoadipoyl)-L-cysteinyl-D- gamma , delta -didehydroisoleucine with isopenicillin N synthetase. The 2 alpha -vinylpenam product is converted by known methods to the 6 beta -amino-2 alpha -vinyl-2 beta -methylpenam-3-carboxylic acid nucleus and the latter is N-acylated to provide corresponding 6 beta -acylaminopenams.
Inventors:
JIYATSUKU EDOWAADO BOORUDOUIN
Application Number:
JP10792887A
Publication Date:
July 30, 1988
Filing Date:
April 28, 1987
Export Citation:
Assignee:
CHIYAANSERAA MASUTAAZU & SUKAR
International Classes:
A61K31/43; A61P31/04; C07D499/00; C07D499/04; C07D499/42; C07D499/44; C07D499/60; C07D499/64; C07D499/70; C12P17/18; C07D499/72; C07D499/76; C07D499/78; C12P37/00; (IPC1-7): A61K31/43; C07D499/42; C07D499/60; C07D499/64; C07D499/70; C07D499/72; C07D499/76; C07D499/78; C12P17/18
Attorney, Agent or Firm:
Aoyama Aoi