Title:
20(S)-ジンセノサイドRh2の合成方法
Document Type and Number:
Japanese Patent JP4856071
Kind Code:
B2
Abstract:
A synthetic method of 20(s)-ginsenoside Rh2, that is 20(S)-protopanaxdiol-3-O-beta-D-glucopyranoside, is comprised of: protecting protopanaxdiol (A1) selectively first to produce monosubstituted protopanaxdiol (A2); and Glycosidating the monosubstituted protopanaxdiol with Glucopyranosyl donor in the presence of Lewis acid catalyst; Deprotecting the product; Then separating and purifying to obtain 20(s)-ginsenoside Rh2. The method is conducted under mild condition at low cost, and affords product with high stereoselectivity, high yield and purity. Therefore, the synthetic method of the present invention is suitable for production on large scale.
Inventors:
Huy, Youngzen
Jan, Tiki
Ryu, Yun Yao
Ten, Jin Jun
Seey, Huikin
Chan, Gee
Jan, Tiki
Ryu, Yun Yao
Ten, Jin Jun
Seey, Huikin
Chan, Gee
Application Number:
JP2007522899A
Publication Date:
January 18, 2012
Filing Date:
May 16, 2005
Export Citation:
Assignee:
Shanghai Innovative Research Center of Traditional Chinese Medicine
Shanghai Farm Valley Coop.
Shanghai Farm Valley Coop.
International Classes:
C07J17/00; C07J9/00
Domestic Patent References:
| JPH08208688A | 1996-08-13 |
Foreign References:
| WO1998040399A1 | 1998-09-17 |
Attorney, Agent or Firm:
Hiroe Associates Patent Office
Takenori Hiroe
Takanobu Takekawa
High Shinichi Ara
Tsutomu Nishio
Takenori Hiroe
Takanobu Takekawa
High Shinichi Ara
Tsutomu Nishio