Title:
(20S,22E)-2-メチレン-19-ノル-22-エン-1α,25-ジヒドロキシビタミンD3類似体
Document Type and Number:
Japanese Patent JP2013506685
Kind Code:
A
Abstract:
This invention discloses (20S,22E)-2-methylene-19-nor-22-ene-1alpha,25-dihydroxyvitamin D3 analogs, and specifically(20S,22E)-2-methylene-19-nor-22-ene-1alpha,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits significant vitamin D receptor binding activity and transcription activity as well as pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent, especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.
Inventors:
Deluca, Hector, F.
Grijiwax, Powell
Plum, loli, a.
Kruget-Dame, Margaret
Grijiwax, Powell
Plum, loli, a.
Kruget-Dame, Margaret
Application Number:
JP2012532323A
Publication Date:
February 28, 2013
Filing Date:
September 30, 2010
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
C07C401/00; A61K31/593; A61K31/695; A61P1/00; A61P3/02; A61P13/08; A61P15/00; A61P17/00; A61P35/00; A61P35/02; C07F7/18
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Nao Oda