Title:
21*211DIHAL0 SUBSTITUTED 16 ALPHA*17 ALPHAA ACETONIDE STEROID
Document Type and Number:
Japanese Patent JPS5331652
Kind Code:
A
Abstract:
Novel, topically-active anti-inflammatory steroids are represented by the formula wherein X is fluoro, chloro or hydrogen; X1 is fluoro, chloro, bromo, or hydrogen; X2 is hydroxy or may be chloro when X1 is chloro; and X3 and X4 are independently fluoro, chloro or bromo. These steroids are prepared by formylating at the 21-position a 16 alpha ,17 beta -isopropylidenedioxypregna-1,4,9(11)-triene-3,20-dione or the corresponding 21-fluoro compound, halogenating at the 21 position, deformylating, then reacting to add the desired components at the 9 alpha and 11 beta positions.
Inventors:
TSUNGUUTEII RII
MAIKURU MAAKUSU
RUIZU SURUUPU
MAIKURU MAAKUSU
RUIZU SURUUPU
Application Number:
JP9150177A
Publication Date:
March 25, 1978
Filing Date:
August 01, 1977
Export Citation:
Assignee:
SYNTEX INC
International Classes:
A61K31/57; A61P29/00; C07J71/00; (IPC1-7): A61K31/57; C07J5/00