Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
2,3-BRIDGED 1,4-DIHYDROPYRIDINES, THEIR PREPARATION AND USE THEREOF AS MEDICAMENT
Document Type and Number:
Japanese Patent JPH0859622
Kind Code:
A
Abstract:

To obtain a new compound capable of manifesting specific and selective modulating actions on a potassium channel and suitable for use as a medicament for combating diseases in the central nervous system and sickle cell anemia.

This compound is represented by formula I [R is a 6-10C aryl, pyridyl (which can optionally be substituted with CN, a halogen, CF3 or a ≤6C alkylthio); R1 is H, a ≤8C linear or branched chain alkyl; R2 is a ≤6C linear or branched chain alkyl or a 3-6C cycloalkyl; D and E together may form CO-(CH2)3, CO-CH2-C(CH3)2-CH2, CO-O-CH2 or CH2-O-CO-], e.g. isopropyl 4-(2,3- dichlorophenyl)-1,2-dimethyl-5-oxo-1,4,5,7,8-hexahydroquinoline-3-carboxylate. The compound represented by formula I in which D/E is not CH2-O-CO is obtained by reacting an aldehyde represented by the formula R-CHO with compounds represented by formulae II and III and reacting the resultant compound represented by formula IV with an alkylating agent represented by the formula R2-X (X is a halogen).


Inventors:
Urbahns, Klaus
Goldmann, Siegfried
Heine, Hans-georg
Junge, Bodo
Schohe-loop, Rudolf
Sommermeyer, Henning
Glaser, Thomas
Wittka, Reilinde
DE, Vry Jean-marie-viktor
Application Number:
JP1995000234704
Publication Date:
March 05, 1996
Filing Date:
August 18, 1995
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
BAYER AG
International Classes:
C07D491/044; A61K31/395; A61K31/435; A61K31/47; A61P25/00; A61P25/28; C07D215/54; C07D401/04; C07D471/04; C07D491/04; C07D491/048; (IPC1-7): C07D215/54; A61K31/435; A61K31/47; C07D401/04; C07D491/048
Attorney, Agent or Firm:
小田島 平吉