Title:
2,3-DIHYDROINDOLE-3,3-DICARBOXYLIC ACID AND 2,3-DIHYDROINDOLE-3-CARBOXYLIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP3224584
Kind Code:
B2
Abstract:
PURPOSE: To provide two kinds of the new subject carboxylic acid derivatives useful as raw materials for producing optically active compounds which are expected in the application field as an anticancer agent.
CONSTITUTION: A 2,3-dihydroindole-3-carboxylic acid derivative of formula I (R1 is H, 1-4C alkyl; R2 is H, COOR1; X is two H atoms, O, S; R3 is H, amino group-protecting group; R4 is H, nitro, amino; R5 is H, OH-protecting group) and a 2,3-dihydroindole-3-carboxylic acid derivative of formula II (R6, R7 are H, 1-6C alkyl, benzyl, phenyl; Y, Z are O, S, substituted amino), e.g. 6- benzyloxy-3,3-di(methylcarbonyl)-2,3-dihydroindol-2-one and 6-benzyloxy-1-t- butoxycarbonyl-(3S)-hydroxymethyl-2,3-dihydro(1H)-indole. The compound of formula I is obtained from a compound of formula III through a compound of formula IV. The compound of formula II is obtained by reacting a compound of formula V with a compound of formula VI.
More Like This:
Inventors:
Toro Terashima
Yasumichi Fukuda
Yasumichi Fukuda
Application Number:
JP5553792A
Publication Date:
October 29, 2001
Filing Date:
March 13, 1992
Export Citation:
Assignee:
Kyorin Pharmaceutical Co., Ltd.
Sagami Central Chemical Research Institute
Sagami Central Chemical Research Institute
International Classes:
C07D209/42; C07C229/42; C07D209/12; C07D403/06; C07D413/06; C07D417/06; (IPC1-7): C07D209/42; C07D209/12; C07D403/06; C07D413/06; C07D417/06
Other References:
【文献】仏国特許1536200(FR,B)
Attorney, Agent or Firm:
Masayuki Kishida (1 person outside)