24-ALDEHYDE STEROID - BONII KAIZAA

Title:

24-ALDEHYDE STEROID

Document Type and Number:

Japanese Patent JPH0372494

Kind Code:

A

Abstract:

NEW MATERIAL: A compound of formula I (formula II is formulae III, IV, etc.).

EXAMPLE: A compound of formula V.

USE: Intermediates for producing 24,25-dihydroxycholesterol or hydroxylated vitamin D3 useful for treatment of calcium metabolism disorders.

PROCESS: The subject compound is obtained, for example, by reacting dissolving a 24-carbon-24-alcohol steroid in methylene chloride, mixing the solution with a methylene chloride solution of chromium trioxide-pyridine complex for oxidation to an aldehyde of formula VII, and treating the aldehyde with p- toluenesulfonic acid for deprotection in a mixed solvent of water and a water- miscible alcohol to remove 3α,5-cyclo group (i-steroid) which is the protecting group, from the compound of formula VII.

More Like This:

JPS6028986	PRODUCTION OF STEROID
WO/2001/032681	PROCESS FOR PRODUCING PHYTOSTEROLS BY SAPONIFICATION IN AN ALCOHOL/WATER SOLVENT

Inventors:

EMIIRU TOOMASU KAIZAA

Application Number:

JP19467790A

Publication Date:

March 27, 1991

Filing Date:

July 23, 1990

Export Citation:

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Assignee:

BONII KAIZAA

International Classes:

C07J9/00; C07J21/00; (IPC1-7): C07J9/00

Attorney, Agent or Firm:

Akihide Sugimura (1 outside)

Next Patent: STEROID DERIVATIVE