Title:
癌に対するオータキシン阻害剤としての２，５−ジアミノ−置換ピリド［４，３−Ｄ］ピリミジン
Document Type and Number:
Japanese Patent JP5697601
Kind Code:
B2
Abstract:
The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
Inventors:
Seaman, Kai
Schulz, Melanie
Stahl, Wolfgang
Cover, ingo
Wienke, Dirk
Clie, Mireille
Schulz, Melanie
Stahl, Wolfgang
Cover, ingo
Wienke, Dirk
Clie, Mireille
Application Number:
JP2011538851A
Publication Date:
April 08, 2015
Filing Date:
November 03, 2009
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K31/519; C07D471/04; A61K31/5377; A61P9/10; A61P17/02; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/06
Domestic Patent References:
| JP9508127A | ||||
| JP2000506847A | ||||
| JP2003523357A | ||||
| JP2007505858A |
Foreign References:
| US20040204386 |
Other References:
Biochemical Pharmacology,1997年,Vol.54,p.877-887
Attorney, Agent or Firm:
Akio Miyazaki
Masaaki Ogata
Masaaki Ogata