26,26,26,27,27,27-HEXAFLUORO-1ALPHA,25-DIHYDROXYCHOLESTEROL

Title:

26,26,26,27,27,27-HEXAFLUORO-1ALPHA,25-DIHYDROXYCHOLESTEROL

Document Type and Number:

Japanese Patent JPH0625280

Kind Code:

A

Abstract:

PURPOSE: To provide new 26,26,26,27,27,27-hexafluoro-1 α,25-dihydroxycholesterol as an intermediate for the synthesis of a new vitamin D3 deriv. excellent in activity similar to that of vitamin D and useful as a drug for renal osteodystrophy, osteoporosis, etc.

CONSTITUTION: 26,26,26,27,27,27-Hexafluoro-25-hydroxycholesterol-3-THP ether of formula I is hydrolyzed with p-toluenesulfonic acid in a CH2Cl2-methanol mixed solvent, the resultant product is oxidized with dichlorocyanobenzoquinone in dioxane, the resultant compd. of formula II is treated with an alkali hydrogen peroxide and the resultant 1,2-epoxide is reduced with metal lithium and ammonium chloride in an ammonia-THF soln. to obtain the objective 26,26,26,27,27,27- hexafluoro-1 α,25-dihydroxycholesterol.

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Inventors:

HEKUTAA EFU DERUUKA
TANAKA YOKO
IKEGAWA NOBUO
KOBAYASHI YOSHIRO

Application Number:

JP1574891A

Publication Date:

February 01, 1994

Filing Date:

January 17, 1991

Export Citation:

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Assignee:

WISCONSIN ALUMNI RES FOUND

International Classes:

A61K31/59; A61P3/02; C07J9/00; (IPC1-7): C07J9/00

Foreign References:

US4199518A	1980-04-22
US4248791A	1981-02-03

Attorney, Agent or Firm:

Takao Kawasaki (1 outside)

Next Patent: 2-DEOXY-3-ACYLBRASSINOSTEROID