2H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR

Title:

2H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR

Document Type and Number:

Japanese Patent JP2023179420

Kind Code:

A

Abstract:

To provide agonists of Toll-like receptor 7 (TLR7), their conjugates, as well as methods for the production and use of the agonists and their conjugates.SOLUTION: Compounds of formula II are useful as agonists of TLR7 and can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent or a vaccine adjuvant.SELECTED DRAWING: None

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Inventors:

YAM B POUDEL
SANJEEV GANGWAR
HE LIQI
PRASANNA SIVAPRAKASAM

Application Number:

JP2023135513A

Publication Date:

December 19, 2023

Filing Date:

August 23, 2023

Export Citation:

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Assignee:

BRISTOL MYERS SQUIBB CO

International Classes:

A61K31/519; A61K31/5377; A61K31/551; A61P35/00; A61P37/04; C07D487/04; C07D519/00

Attorney, Agent or Firm:

Norito Yamao
Nagatoshi Shinagawa
Futami Kamahira
Masahiro Suwon
Wu Yingyan

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