Title:
フラビウィルス感染治療のための2′および3′-ヌクレオシドプロドラッグ
Document Type and Number:
Japanese Patent JP5087211
Kind Code:
B2
Abstract:
2' and 3'-Prodrugs of l', 2', 3' or 4'-branched ß-D or ß-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
Inventors:
Somadosi, Jiyan-Pierre
La Cotura, Paolo
Strawr, Lichyard
Goslan, Jill
La Cotura, Paolo
Strawr, Lichyard
Goslan, Jill
Application Number:
JP2004517162A
Publication Date:
December 05, 2012
Filing Date:
June 27, 2003
Export Citation:
Assignee:
Idenix (Cayman) Limited
Center Nacional Dou la Lucier Siyu Cyantei Fique (Say N Ale S)
Unibercita Detsuri Stoday Day Cagliari
Center Nacional Dou la Lucier Siyu Cyantei Fique (Say N Ale S)
Unibercita Detsuri Stoday Day Cagliari
International Classes:
A61K31/7068; A61K9/20; C07H19/06; A61K9/48; A61K31/7056; A61K31/706; A61K31/7064; A61K31/7072; A61K31/7076; A61K31/708; A61K38/00; A61K38/21; A61K45/00; A61P31/14; A61P43/00; C07H19/00; C07H19/04; C07H19/044; C07H19/048; C07H19/052; C07H19/056; C07H19/067; C07H19/10; C07H19/12; C07H19/14; C07H19/16; C07H19/167; C07H19/20; C07H19/22; C07H19/23
Domestic Patent References:
| JP2001503767A | ||||
| JP1104093A | ||||
| JP10512281A | ||||
| JP2032094A | ||||
| JP3083994A | ||||
| JP3002193A | ||||
| JP5097887A |
Foreign References:
| WO2001092282A1 | ||||
| WO2001090121A1 | ||||
| WO2001096353A1 | ||||
| WO2001091737A1 | ||||
| GB1163103B | ||||
| GB1209654B |
Other References:
NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 9, no. 9, 1981,p115-118
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 32, no. 7, 1967, p2663-2667
J. Med. Chem., vol. 41, no.10, 1998, p1708-1715
JOURNAL OF ORGANIC CHEMISTRY, vol. 62, no. 6, 1997, p1754-1759
SYNTHESIS, no. 8, 1992 , p773-778
HELV. CHIM. ACTA, vol. 62, 1979, p689-695
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 39, 1974, p2115-2123
BIOCHEMISTRY, vol. 31, 1992, p11210-11215
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 37, 1972, p2059-2065
CARBOHYDRATE RESEARCH, vol.124,1983, p75-96
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 32, no. 7, 1967, p2663-2667
J. Med. Chem., vol. 41, no.10, 1998, p1708-1715
JOURNAL OF ORGANIC CHEMISTRY, vol. 62, no. 6, 1997, p1754-1759
SYNTHESIS, no. 8, 1992 , p773-778
HELV. CHIM. ACTA, vol. 62, 1979, p689-695
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 39, 1974, p2115-2123
BIOCHEMISTRY, vol. 31, 1992, p11210-11215
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 37, 1972, p2059-2065
CARBOHYDRATE RESEARCH, vol.124,1983, p75-96
Attorney, Agent or Firm:
Yoshio Kawaguchi
Chihiro Watanabe
Katsuma Osaki
Chihiro Watanabe
Katsuma Osaki