2S and (R [3]) -N- (2- (3-pillage nil) (methyl) -1-azabicyclo [2.2. 2] Octa - 3- Il ) benzofuran 2- Carboxamide , its new salt form, and directions for use for the same

Japanese Patent JP6106549

B2

The present invention related to the ±7-selective ligand (2S,3R)-N-(2-((3-pyridinyl)methyl)-l-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof and (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof, substantially free of (2R,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof, (2S,3S)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof and (2R,3S)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene -2-carboxamide or a pharmaceutical acceptable salt thereof.

WO/1998/054151	PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS
JPH02503569	[Title of the Invention] A new compound
WO/1999/031088	TRIAZINE ANGIOGENESIS INHIBITORS

Bencherif, Melouan
Benson, Lisa
Dal, Gary Maurice
Fedorov, Nikolai
Gut, Gregory Jay.
Genus, John
Jordan, Christenzy.
Matthew, Jacob
Maslov, Anatoly A.
Miao, orchid
Muñoz, Julio A.
Pfeiffer, Inigo
Pfeiffer, Sondra
Phillips, Teresa Wai.

JP2013148091A

April 05, 2017

July 17, 2013

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Targacept, Incorporated

C07D453/02; A61K31/444; A61P9/10; A61P9/14; A61P21/00; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P29/00

JP2006518746A
JP5358573B2

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka

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