Title:
3-[2-{(メチルスルホニル)オキシ}エトキシ]-4-(トリフェニルメトキシ)-1-ブタノール、メタンスルホネートの調製方法
Document Type and Number:
Japanese Patent JP2006506941
Kind Code:
A
Abstract:
A method of producing (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methane sulfonate using 1,3-butadiene and a ketoethanal to form an intermediate racemic mixture. The racemic mixture is resolved to remove one isomer from the reaction product mixture. Following resolution, the following steps are performed: reduce the isomer to an alcohol, react the alcohol with triphenylmethyl chloride, ozonalyze the resulting reaction product, reduce the ozonalyzed product to yield a diol and react the diol with a methane sulfonyl compound to form (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methane sulfonate. Alternatively, the racemic mixture may first be reduced and the resulting racemic alcohol mixture is resolved to isolate one isomer of the alcohol and the remaining process steps are followed.
Inventors:
Kyle, Gene-Claude
Application Number:
JP2002559825A
Publication Date:
March 02, 2006
Filing Date:
October 30, 2001
Export Citation:
Assignee:
Ppee Industries Industries Ohio, Inc.
International Classes:
C12P41/00; C07C303/28; C07C309/66; C07D309/24; C12P11/00; C07B53/00; C12R1/07
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita