Title:
3-O-heteroaryl ingenol
Document Type and Number:
Japanese Patent JP6216781
Kind Code:
B2
Abstract:
The present invention relates to a compound according to formula (I) wherein R1 represents optionally substituted heteroaryl, and pharmaceutically acceptable salts, hydrates, solvates or pharmaceutically acceptable and physiologically cleavable esters thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. diseases associated with hyperplasia, neoplasia or dysplasia, with said compounds, to methods of treatment of cosmetic indications with said compounds, and to the use of said compounds in the manufacture of medicaments.
Inventors:
Lian Shifu
Thomas Hague Bali
Bjarne Neremark
Christopher Mornson
Carsten Rittersgow
Gunner Glue-Seresen
Thomas Hague Bali
Bjarne Neremark
Christopher Mornson
Carsten Rittersgow
Gunner Glue-Seresen
Application Number:
JP2015518999A
Publication Date:
October 18, 2017
Filing Date:
June 21, 2013
Export Citation:
Assignee:
LEO LABORATORIES LIMITED
International Classes:
C07D213/64; A61K31/416; A61K31/4164; A61K31/423; A61K31/4245; A61K31/4355; A61K31/4365; A61K31/44; A61K31/4402; A61K31/472; A61K31/505; A61K45/00; A61P15/00; A61P17/00; A61P17/12; A61P35/00; C07D213/85; C07D217/24; C07D231/56; C07D233/70; C07D239/34; C07D261/20; C07D271/07; C07D405/12; C07D413/12; C07D491/048; C07D495/04
Domestic Patent References:
| JP55136221A | ||||
| JP2014512331A | ||||
| JP2010524978A |
Other References:
Blanco-Molina, M. 他,Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-κB independent pathway,Chemistry & Biology,2001年,Vol.8, No.8,p.767-778
Appendino, Giovanni 他,Synthesis of modified ingenol esters,European Journal of Organic Chemistry,1999年,No.12,p.3413-3420
Sorg, Bernd 他,On the chemistry of ingenol. III. Synthesis of 3-deoxy-3-oxoingenol and its C-5 esters, and synthesis of ethers and acetals of ingenol,Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie,1982年,Vol.37B, No.12,p.1640-1647
Appendino, Giovanni 他,Synthesis of modified ingenol esters,European Journal of Organic Chemistry,1999年,No.12,p.3413-3420
Sorg, Bernd 他,On the chemistry of ingenol. III. Synthesis of 3-deoxy-3-oxoingenol and its C-5 esters, and synthesis of ethers and acetals of ingenol,Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie,1982年,Vol.37B, No.12,p.1640-1647
Attorney, Agent or Firm:
Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Yasushi Ochiai
Aoyama Aoi
Michiko Matsutani
Yasushi Ochiai
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