Title:
ＨＤＡＣ阻害薬としての３−アルキル−４−アミド−二環式［４，５，０］ヒドロキサム酸
Document Type and Number:
Japanese Patent JP6668362
Kind Code:
B2
Abstract:
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
Inventors:
Jen, Xiao Chang
Nguyen, Pui Yi
Han, Vinson
Thomason, Jennifer Earl.
Sabrocchi, Mary-Margaret
Ryu, Tui Sheng
Davis, Heather
Radnitskaya, Alexandra
Lancia, David Earl. Junior
Bear, Kenneth W.
Milan, David S.
Martin, Matthew W..
Nguyen, Pui Yi
Han, Vinson
Thomason, Jennifer Earl.
Sabrocchi, Mary-Margaret
Ryu, Tui Sheng
Davis, Heather
Radnitskaya, Alexandra
Lancia, David Earl. Junior
Bear, Kenneth W.
Milan, David S.
Martin, Matthew W..
Application Number:
JP2017540742A
Publication Date:
March 18, 2020
Filing Date:
February 02, 2016
Export Citation:
Assignee:
FORMA THERAPEUTICS,INC.
International Classes:
C07D243/14; A61K31/5513; A61K31/553; A61P1/04; A61P3/00; A61P7/00; A61P9/00; A61P17/06; A61P19/02; A61P19/04; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C07D267/10; C07D413/06; C07D413/10; C07D413/12; C07D413/14; C07D491/08; C07D491/107; C07D493/08; C07D495/10; C07D498/04
Domestic Patent References:
| JP2009509923A | ||||
| JP2012530703A |
Foreign References:
| WO2005108367A1 |
Other References:
Journal of Medicinal Chemistry,2013年,56,7201-7211
PLOS Pathogens,2013年,9(9),1-15,e1003645
PLOS Pathogens,2013年,9(9),1-15,e1003645
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto