Title:
3-AMINO-DIHYDRO-(1)-BENZOPYRANE AND BENZOTHIOPYRANE
Document Type and Number:
Japanese Patent JPS63277671
Kind Code:
A
Abstract:
Compounds of the formula: in which Z denotes oxygen or sulphur, R denotes hydrogen or lower alkyl, R1 denotes hydrogen, lower alkyl or aryl-lower alkyl, R2 denotes hydrogen, lower alkyl or aryl-lower alkyl or R1 and R2 together denote alkylene having 4-6 C atoms, R3 denotes hydrogen, hydroxyl, lower alkoxy, aryl-lower alkoxy, acyloxy or aryloxy in compounds having the meaning sulphur for Z, R3 denotes hydroxyl, lower alkoxy, aryl-lower alkoxy, acyloxy or aryloxy in compounds having the meaning oxygen for Z and R3 is bonded in the 5- or 8-position in compounds having the meaning oxygen for Z, R4 and R5 independently of one another denote hydrogen, lower alkyl or halogen, and pharmaceutically acceptable salts thereof and mono- or di-S-oxides of compounds of the formula I in which Z denotes sulphur. The compounds can be used as modulators for the receptors of the central nervous system, for example as serotonin receptor antagonists in the treatment of disorders of the central nervous system.
Inventors:
ARAN JIEI HATSUCHISON
Application Number:
JP4334088A
Publication Date:
November 15, 1988
Filing Date:
February 27, 1988
Export Citation:
Assignee:
CIBA GEIGY AG
International Classes:
A61K31/35; A61K31/352; A61K31/38; A61K31/382; A61K31/395; A61P25/00; A61P25/18; A61P25/20; A61P25/24; A61P25/26; C07D311/04; C07D311/58; C07D335/06; (IPC1-7): A61K31/35; A61K31/38; A61K31/395; C07D311/04; C07D335/06
Attorney, Agent or Firm:
Aoki Akira (3 outside)