3-AMINOMETHYLPYRROLE-1-YL-ALKYLAMINE AND REMEDY CONTAINING SAME

Japanese Patent JPS6256470

A

Compounds of the formula I in which R<1> and R<2> independently of one another denote a hydrogen atom or a C1-C12-alkyl, C3-C12-alkenyl or C3-C12-cycloalkyl radical which can be substituted by a phenyl or naphthyl radical which, in turn, can be substituted by 1 or 2 C1-3-alkyl or C1-3-alkoxy groups or by 1 or 2 fluorine, chlorine or bromine atoms or by a trifluoromethyl, carboxyl, (C1-5-alkoxy)-carbonyl, cyano or C1-4-acylamido group, or by a 5-membered aromatic ring having 1 to 3 nitrogen atoms or an oxygen or sulphur atom and optionally 1-2 nitrogen atoms, or by a 6-membered aromatic ring having 1 to 3 nitrogen atoms, where these heteroaromatic rings optionally carry 1 to 3 C1-3-alkyl groups, or R<1> and R<2>, together with the nitrogen atom, form a saturated heterocyclic ring having 4 to 12 ring members which is substituted by a phenyl and/or a hydroxyl, C1-4-acyl, (C1-5-alkoxy)-carbonyl, nitrile, n-phenyl-n-(C1-4-acyl)amino or n-benzamido group or a benzimidazolin-2-on-1-yl radical and/or by 1 to 3 C1-4-alkyl groups or can carry a fused benzene ring, R<3>, R<4> and R<5> independently of one another denote hydrogen atoms or C1-3-alkyl groups, where R<4> and R<5>, together with the double bond, can also denote a benzene ring, A denotes a C2-8-alkylene radical, which can be olefinically or acetylenically monounsaturated and in which a carbon atom can be replaced by an oxygen atom, a sulphur atom or a phenylene group, B denotes one of the groups B<1> to B<6>: in which E denotes S, CH-NO2 or N-CN, R<6> denotes a hydrogen atom or a C1-3-alkyl radical which can be substituted by a 5-membered aromatic ring having 1 to 3 nitrogen atoms or an oxygen or sulphur atom and optionally 1-2 nitrogen atoms or a 6-membered aromatic ring having 1 to 3 nitrogen atoms, where these heteroaromatic rings optionally carry 1 to 3 C1-3-alkyl groups, or can be substituted by a hydroxyl or C1-4-alkoxy group, R<7> denotes a hydrogen atom or a C1-3-alkyl radical, R<8> denotes an amino group or the radical CH2OR<1><2>, in which R<1><2> represents a hydrogen atom, a C1-3-alkyl radical, a C1-6-acyl group, the benzoyl group, or the tetrahydrofuran-2-yl or tetrahydropyran-2-yl radical, R<9> denotes a C1-6-alkyl radical or a phenyl group which can each be substituted by 1 or 2 C1-3-alkyl, or C1-3-alkoxy groups or chlorine or bromine atoms or by a methylenedioxo radical, or denotes a 5-membered aromatic ring having 1 to 3 nitrogen atoms or an oxygen or sulphur atom and optionally 1-2 nitrogen atoms or a 6-membered aromatic ring having 1 to 3 nitrogen atoms, where these heteroaromatic rings optionally carry 1 to 3 C1-3-alkyl groups, R<1><0> and R<1><1> denote hydrogen atoms or C1-3-alkyl radicals which can be substituted by a phenyl group which can each in turn be substituted by 1 or 2 C1-3-alkyl or C1-3-alkoxy groups or chlorine or bromine atoms, or by a 5-membered aromatic ring having 1 to 3 nitrogen atoms or an oxygen or sulphur atom and optionally 1-2 nitrogen atoms or a 6-membered aromatic ring having 1 to 3 nitrogen atoms, where these heteroaromatic rings optionally carry 1 to 3 C1-3-alkyl groups, or by a hydroxyl or C1-3-alkoxy group, m denotes the number 0, 1 or 2 and Ar represents a fused benzene or thiophene ring, and their physiologically tolerated salts, and the compounds or their salts as therapeutic agents containing active compound.

WO/1996/025397	INDOLE DERIVATIVES WITH AFFINITY FOR THE CANNABINOID RECEPTOR
JPH06501681	[Title of Invention] Inhibitor of Retrovirus Protease
JP3911293	Succinic acid derivative that inhibits protease

KAARU HAINTSU GAISU
WARUTAA HIMUMERE
DEIITAA DEEGUNAA
HARUDOO JIIGERU
YOOZEFU GURIISU
DEIITAA RENKE

JP20193586A

March 12, 1987

August 29, 1986

Click for automatic bibliography generation  

BASF AG

A61K31/40; A61K31/403; A61K31/404; A61K31/41; A61K31/425; A61K31/44; A61K31/4427; A61K31/47; A61P1/04; A61P43/00; C07D207/335; C07D209/14; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D403/14; C07D405/06; C07D409/06; C07D417/12; C07D417/14; C07D495/04; C07D513/04; C07D207/32; (IPC1-7): A61K31/40; A61K31/41; A61K31/425; A61K31/44; A61K31/47; C07D207/00; C07D207/335; C07D209/14; C07D213/00; C07D217/00; C07D249/00; C07D275/00; C07D285/00; C07D401/12; C07D403/12; C07D417/12; C07D513/04

Masao Kobayashi

Previous Patent: Spiro [2.5] octane 5, the manufacture process of 7-dione

Next Patent: EPOXY RESIN MOLDING MATERIAL FOR SEALING