3-AMINOPYRROLIDINE DERIVATIVE AS MODULATOR OF CHEMOKINE RECEPTOR

Title:

3-AMINOPYRROLIDINE DERIVATIVE AS MODULATOR OF CHEMOKINE RECEPTOR

Document Type and Number:

Japanese Patent JP2011251987

Kind Code:

A

Abstract:

To provide novel compounds used as modulators of chemokine receptors, and to provide a pharmaceutical composition containing the same.

This invention relates to a 3-aminopyrrolidine derivative shown by the formula, and the pharmaceutical composition containing the compounds. In the formula, X is selected from the group consisting of aryl, heterocycle heteroaryl, carbocycle and the like; Y is a bond, or is selected from the group consisting of oxygen, sulfur, nitrogen, amide bond and the like; Z is selected from the group consisting of carbocycle, aryl, heterocycle or heteroaryl and the like; R1 is independently selected from the group consisting of a carbocycle, heterocycle, aryl, heteroaryl, and the like; R2 is independently selected from the group consisting of H, amino, mono- or di-substituted amino, OH, carboxyl and the like; R3, R4, R5, and R6 are independently selected from the group consisting of H, amino, OH, alkyl, haloalkyl; and R7 and R8 are independently selected from the group consisting of hydrogen, alkyl and the like. The pharmaceutical composition is suitable for treating inflammatory and autoimmune diseases.

Inventors:

XUE CHU-BIAO
METCALF BRIAN
FENG HAO
CAO GANFENG
HUANG TAISHING
ZHENG CHANGSHENG
ROBINSON DARIUS J
HAN AMY QI

Application Number:

JP2011160080A

Publication Date:

December 15, 2011

Filing Date:

July 21, 2011

Export Citation:

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Assignee:

INCYTE CORP

International Classes:

C07D207/14; A61K31/40; A61K31/4025; A61K31/407; A61K31/4155; A61K31/416; A61K31/4178; A61K31/422; A61K31/427; A61K31/428; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/4709; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61P1/04; A61P1/16; A61P1/18; A61P7/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P29/00; A61P29/02; A61P31/12; A61P37/02; A61P37/04; A61P37/06; A61P43/00; C07D401/08; C07D401/10; C07D401/12; C07D401/14; C07D403/08; C07D403/10; C07D405/04; C07D405/08; C07D405/10; C07D405/14; C07D409/08; C07D413/10; C07D413/14; C07D417/08; C07D417/10; C07D417/14; C07D491/107; C07D495/10

Domestic Patent References:

JP2002505684A	2002-02-19
JPH10298180A	1998-11-10
JP4828829B2	2011-11-30

Foreign References:

WO2001028987A1	2001-04-26
WO2000026186A1	2000-05-11
WO1995008533A1	1995-03-30

Attorney, Agent or Firm:

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Yasushi Ochiai

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