NEW MATERIAL:A compound expressed by formula I (R1 is H or acetyl; R2 is 1-6C alkoxy, cholestenyl, cholestanyl or halogen; R3 is H, 1-6C alkyl, aryl, aralkyl, alkali metal or NH+4).
USE: The compound expressed by formula I has nerve activation action, immune reguating action, antiphlogistic action, etc.
PREPARATION: N-Acetyl-D-neuramic acid is subjected to methanol treatment and then acetic anhydride-pyridine treatment to give a compound expressed by formula II, which is then reacted with dinitrogen tetraoxide in the presence of sodium acetate in acetic acid and further refluxed in carbon tetrachloride while heating to afford a compound expressed by formula III. The compound expressed by formula III is further subjected to K2CO3-methanol treatment and then 0.1N-NaOH treatment and heated in an aqueous solution of CF3OOH and subjected to demethylation to provide the aimed compound.
NAKAMURA MITSUNOBU
SHIRAI RYUICHI
TAKAYANAGI HIROAKI
IKEDA MOHANDO CO